TH
-
Official Full Name
tyrosine hydroxylase -
Overview
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen (O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs). -
Synonyms
TH;tyrosine hydroxylase;TYH;DYT14;DYT5b;tyrosine 3-monooxygenase;dystonia 14;tyrosine 3-hydroxylase
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Cattle
- Zebrafish
- Human
- Insect Cells
- Mammalian Cells
- E.coli
- HEK293
- His
- GST&His
- His&T7
- His&S
- Non
- Avi&Fc&His
- DDK&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TH-1916H | Recombinant Human Tyrosine Hydroxylase, His-tagged | Human | Human | His | 2-497 a.a. | |
| TH-2553H | Recombinant Human TH protein, His-tagged | Insect Cells | Human | His | Pro2-Gly497 |
|
| Th-2554M | Recombinant Mouse Th protein, His-tagged | Insect Cells | Mouse | His | Pro2-Ser498 |
|
| Th-25M | Recombinant Mouse Th protein, His-tagged | Insect Cells | Mouse | His |
|
|
| TH-6046R | Recombinant Rat TH Protein | Mammalian Cells | Rat | His |
|
|
| TH-6368C | Recombinant Chicken TH | Mammalian Cells | Chicken | His |
|
|
| TH-6961C | Recombinant Cattle TH protein, His & GST-tagged | E.coli | Cattle | GST&His | Ala45~Pro214 |
|
| TH-6962H | Recombinant Human TH protein, His & T7-tagged | E.coli | Human | His&T7 | Leu82~Cys310 |
|
| Th-6963R | Recombinant Rat Th protein, His & S-tagged | E.coli | Rat | His&S | Phe34~Leu301 |
|
| TH-8763Z | Recombinant Zebrafish TH | Mammalian Cells | Zebrafish | His |
|
|
| TH-485MCL | Recombinant Mouse TH cell lysate | Insect Cells | Mouse | Non |
|
|
| TH-527HCL | Recombinant Human TH cell lysate | Insect Cells | Human | Non |
|
|
| TH-5703R | Recombinant Rat TH Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
|
|
| TH-5703R-B | Recombinant Rat TH Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| Th-6403M | Recombinant Mouse Th Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
|
|
| TH-6439H | Recombinant Human TH Protein (Met1-Ile260), N-His tagged | E.coli | Human | His | Met1-Ile260 |
|
| TH-899H | Recombinant Human TH Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
|
Involved Pathway
TH involved in several pathways and played different roles in them. We selected most pathways TH participated on our site, such as Tyrosine metabolism,Metabolic pathways,Dopaminergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with TH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | CREB3L4,HIST1H2AE,PRKACA,H2AFY,HIST1H3C,HIST1H2AC,CALM1,HIST1H2AB,HIST1H2BP,HIST1H3G |
| Prolactin signaling pathway | CSN2,FOS,AKT2,CSH,GRB2,PIK3CB,LHB,KRAS,CCND1,TNFRSF11A |
| Parkinsons disease | NDUFB9,UQCRH,APAF1,HTRA2,ATP5J,SNCAIP,PPIF,NDUFA4L2,UBE2G2,SLC18A2 |
| Dopaminergic synapse | MAPK13,GNAS,MAPK11,GRIA4,ATF6B,GNG13,COMT,DRD1A,CAMK2D,MAOB |
| Tyrosine metabolism | AOX2P,GSTZ1,ADH2-1,TYRP1B,GOT2B,AOX4,AOC2,AOX3,MAOB,GOT2A |
| Metabolic pathways | CYP4F14,ITGB1BP3,GALNT2,B3GAT3,TALDO1,RPE,PIGA,GPAT2,POLR2E,PLCD3 |
| Cocaine addiction | GNAI2,DRD1,GRIA2,GRM2,GRIN3A,RELA,CREB3L3,PRKACA,BDNF,DRD2 |
Protein Function
TH has several biochemical functions, for example, amino acid binding,dopamine binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TH itself. We selected most functions TH had, and list some proteins which have the same functions with TH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dopamine binding | DRD2A,DRD1A,DRD4,DRD1,ADRB2,DRD2B,DRD1B,DRD5,GPR143,SLC6A3 |
| oxygen binding | CYP2C38,CYP1B1,CYP2AA2,Adgb,CYP2AD3,CYP2C50,CYP2AA9,CYP2K18,HBZ,CYP2A7 |
| protein binding | CHMP1A,DPPA4,TGFBRAP1,FGFRL1A,RFC5,SPINK2,NADK,CLOCKA,THSD4,COBL |
| amino acid binding | TAT,AARS2,TDO2,AARS,KARS,ASS1,TPH1,AGXT,GCHFR,GOT2 |
| tetrahydrobiopterin binding | NOS1,NOS3,NOS2 |
| enzyme binding | PRKDC,HINFP,TSPAN10,MSH2,DYM,DAOA,GBP1,ATP2A2,CTNNB1,ATP6AP2 |
| ferric iron binding | FTH1B,Trf,FTHL17,ACP5,FTH1,TF,FXN,FTL,FTH1A,FTMT |
| protein domain specific binding | TFDP1,PICK1,GABRR3,RAN,IGBP1,VCP,NLRP1,MITD1,DDC,PHRF1 |
| tyrosine 3-monooxygenase activity | TH2 |
Interacting Protein
TH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TH here. Most of them are supplied by our site. Hope this information will be useful for your research of TH.
YWHAZ;YWHAG;YWHAZ;YWHAH
Resources
Related Services
Related Products
References
- Geis, C; Ritter, C; et al. The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. EXPERIMENTAL NEUROLOGY 265:8-21(2015).
- Mahler, M; Fritzler, MJ; et al. Autoantibodies to the mitochondrial RNA processing (MRP) complex also known as Th/To autoantigen. AUTOIMMUNITY REVIEWS 14:254-257(2015).
